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The 2025 NEJM trial comparing tirzepatide directly against semaglutide showed 20.2% versus 13.7% weight loss over the same treatment period

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These results indicate that treatment with GABA, DSIP-CBBBP and more effectively reduced wakefulness time, with DSIP-CBBBP showing the most substantial reduction, suggesting its potential as a therapeutic agent for mitigating insomnia