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PND mice exhibited reduced recognition index, discrimination index, and novel arm entries in the Y-maze test, and these deficits were significantly restored by Fer-1 treatment (Figs

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Interestingly, one Smad7 antisense oligonucleotide, mongersen, was recently shown in a double-blind controlled trial to enhance the 15-day remission rate versus placebo in patients with Crohn’s disease (Monteleone 2015)