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Enhanced carotenoid production in Chlamydomonas reinhardtii by overexpression of endogenousand exogenous beta-carotene ketolase (BKT) genes

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Amongst them, HK-II has been found to be specifically expressed in RA synovial lining and has a function in regulating FLS aggressiveness, and overexpression of HK-II leads to an increased ability of FLS migration and invasion (45)