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Tirzepatide is FDA-approved for type 2 diabetes (as Mounjaro ) and weight loss (as Zepbound )

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"Under pro-inflammatory conditions, some of the major NAD+ consumers, such as PARPs, become highly activated, tilting the scales of NAD+ homeostasis toward excessive consumption, quickly depleting intracellular NAD+ stores, and leading to mitochondrial dysfunction", explains research from Fahmida Jahan and colleagues at the University of Ottawa