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Mechanistically, the combination targets multiple nodes of appetite and metabolic regulation: GLP-1 receptor activation in the hypothalamus and brainstem reduces appetite and slows gastric emptying while also enhancing insulin secretion and insulin sensitivity

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Decrease dose consideration: Persistent side effects including headaches, fatigue, or injection site reactions, excessive response (extremely rapid weight loss suggesting dose may be higher than needed), cost concerns when lower doses might achieve similar results