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This meta-analysis of randomized controlled trials including semaglutide, liraglutide, and dulaglutide found no statistically significant increase in thyroid cancer incidence compared to placebo or active comparators (Faillie et al., 2022, Lancet Diabetes & Endocrinology )

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As of May 31, 2026 the FDA had received more than 730 adverse-event reports for compounded tirzepatide and 990 for compounded semaglutide, some of which it says may be related to dosing errors with compounded injectable products (FDA, content current as of September 1, 2026)