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NO is a reactive molecule that can form reactive nitrogen species such as peroxynitrite and peroxynitrous acid, which are unstable molecules that can result in the production of hydroxyl radicals, thus decreasing NO bioavailability (6)

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Signaling through CD28 and the downstream PI3K/Akt activation determines glucose uptake though GLUT1 upregulation ( Experimental data suggest that GLUT1-mediated glucose transport may have differential effects in CD4 + and CD8 + T cells