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Among them, cystathionine β -synthase (CBS), cystathionine γ -lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) have long been studied based on their roles in H 2 S biogenesis ( 2 S is converted to thiosulfate and sulfate ( Despite the growing understanding of the physiological roles of RSS, the precise contribution of each enzyme to specific biological events remains elusive

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