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As such, the GPx-Tiron method stands as a valuable alternative for assessing oxidative stress and evaluating antioxidant capacity in various biological specimens, paving the way for further research into the critical role of GPx in health and disease

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For instance, curcumin has been shown to upregulate thyroid-specific transcription factors (TTF-1, TTF-2, PAX8) and restore NIS protein expression, thereby overcoming radioiodine (RAI) resistance and enhancing RAI therapy efficacy, offering new perspectives for thyroid cancer treatment (148, 149)

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