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Although many natural and nonnatural substances can affect the activity of G6PD, it is not certain which ones may be important physiologically

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NRF 2 transcriptionally induces the expression of several antioxidant defense proteins involved in iron and ROS metabolism, such as SOD1, GPX4, glutathione synthetase (GCL and GSS), HO-1, and FTH 1 (86–88)