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[5] Conversely, copper supplements or copper-containing topical preparations may increase local copper concentrations and potentially enhance both efficacy and side effect risk

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Impaired individuals exhibit hypomethylation of CpG sites in the CCL11 promoter region, which are then hypermethylated upon supplementation with B12 In impaired individuals, three CpG sites exhibited hypomethylation when compared to the non-impaired group