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This is because berberine derivatives can cross the blood-brain barrier and target mitochondria in the meantime ( 3.4 Other Neurodegenerative Diseases Huntington’s disease is mainly caused by an autosomal dominant mutation in either of the two copies of the Huntingtin (HTT) gene ( Multiple sclerosis, characterized by multiple demyelinating lesions of the spinal cord and brain, has a progressive neurodegenerative pattern ( 4 Limitations of Berberine Treatment Berberine has a variety of activities that may be involved in alleviating Alzheimer’s disease, including antioxidant, neuroprotective, and anti-inflammatory effects ( 5 Conclusion The above evidences suggest that berberine has various roles in neurological diseases, including neuroinflammation, neuroprotection, oxidative stress, etc
