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What the trials found about high-dose oral tablets Kuzminski and colleagues, publishing in Blood (1998), randomized 38 patients with newly diagnosed B12 deficiency to either 2,000 mcg oral cyanocobalamin daily or the standard 1,000 mcg intramuscular schedule
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With severe syndromes, such as vascular and multiorgan failure following major vessel occlusion or similar noxious procedures [66,71,72,73,74,75,76,77,78,79,80,81,82], the particular activation of the collateral pathways (i.e., azygos vein direct blood delivery) might be essential to counteract severe central and peripheral lesions, intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension