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This is presumably due to the dominant ability of pyruvate to enter the mitochondria and increase NADH, although it has the opposite oxidizing effect in the cytosol

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A double-blind, placebo-controlled trial of 262 subjects who were either younger than 65 years and had a chronic degenerative disease or over 65 years with or without chronic disease, but without chronic respiratory disease, received NAC, 1200 mg per day, or placebo for 6 months