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PKA activates the downstream transcription factor, Efg1 , to induce the expression of hyphae-specific genes [81]

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Regulatory Status AOD-9604 is not FDA-approved for any medical use and is listed by the FDA as a bulk drug substance that may present safety risks.⁸ Clinical development was halted after Phase IIb trials failed to meet efficacy endpoints.⁹ Summary AOD-9604 is a synthetic analog of the HGH 177–191 fragment developed for fat-metabolism research