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Interestingly, the same results were not observed in healthy age-matched mice, as 6 weeks of progressive ladder-climbing RT (3 climbs, progression from 50% to 100%MCL, 5 times per week) decreased lipid peroxidation in the cerebral cortex but increased lipid peroxidation in the hippocampus (Feter et al., 2019)

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Functionally, in severe cyclophosphamide hemorrhagic cystitis lesions (i.e., urothelial necrosis, vesical edema, erosion, hemorrhage, inflammation, and ulceration, increased bladder weight), the increased leak point pressure was reversed to the values noted in the normal rats [91]