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The intermittent fasting group saw significant reductions in IGF-1 after two months, with no change in the normal diet group

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Keywords: protein persulfidation, hydrogen sulfide, redox signaling, aging, posttranslational modifications, cysteine Introduction: From Hydrogen Sulfide to Protein Persulfide Ever since Abe and Kimura (1996) demonstrated that hydrogen sulfide (H 2 S) could act as a gasotransmitter (endogenously produced gaseous molecule with signaling properties), interest in H 2 S biology has been growing exponentially