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Recently, by integrating a novel PylRS/PylT pair, CMaPylRS/PylT, which is found in Candidatus Methanomethylophilus alvus and much smaller (825 bp versus 1200–1300 bp), into the CM13d3 helper phage to generate a novel helper phage, CMa13ile40, Hampton et al

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Ten patients (35.7%) responded to one month of treatment with a VAS reduction of ≥ 3