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Generally, ROS and RNS encompass a series of oxygen or nitrogen containing free radicals, mainly generated by cell respiration, like singlet oxygen ( 1 O 2 ), superoxide anion (O 2 − •), peroxynitrite (ONOO–), nitrous acid (HNO 2 ), hydroxyl radical (OH•), nitrotyrosine, nitric oxide (NO), hydrogen peroxide (H 2 O 2 ), and nitrosyl anion (NO−) [62,63]
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The increased levels of apoptosis can destroy healthy nephron filtration function, while heightened proliferation of cyst lining cells drives cyst progression and expansion [85]