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This is due to its continuous exposure to radiation, high concentrations of O 2 , high levels of polyunsaturated fatty acids in the external photoreceptors, and the presence of many chromophores (lipofuscin, melanin, rhodopsin, and cytochrome C oxidase in the retina and retinal pigment epithelial cells (RPE) that also generate ROS in phagocytosis photoreceptor disks by RPE [4,21]

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